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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1903 1
1915 1
1917 1
1919 1
1920 1
1922 2
1923 1
1924 1
1925 1
1926 1
1927 1
1928 1
1929 1
1931 3
1932 2
1933 2
1935 2
1936 1
1940 1
1941 1
1943 2
1944 3
1945 3
1946 7
1947 5
1948 18
1949 12
1950 7
1951 1
1952 1
1953 5
1954 7
1955 4
1956 7
1957 7
1958 8
1959 12
1960 13
1961 17
1962 32
1963 38
1964 40
1965 71
1966 84
1967 80
1968 106
1969 125
1970 130
1971 138
1972 154
1973 162
1974 195
1975 575
1976 577
1977 507
1978 590
1979 611
1980 665
1981 706
1982 807
1983 944
1984 1001
1985 1011
1986 1066
1987 1651
1988 2315
1989 2477
1990 2772
1991 2722
1992 2840
1993 3133
1994 3343
1995 3232
1996 3552
1997 3380
1998 3584
1999 3872
2000 4286
2001 5240
2002 4730
2003 5143
2004 5515
2005 6037
2006 6457
2007 6714
2008 6796
2009 6800
2010 7270
2011 7953
2012 8618
2013 9724
2014 14120
2015 16425
2016 17957
2017 18291
2018 19114
2019 20184
2020 22950
2021 25493
2022 24007
2023 21968
2024 9111
2025 1

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316,210 results

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Page 1
Strategies for immortalization of primary hepatocytes.
Ramboer E, De Craene B, De Kock J, Vanhaecke T, Berx G, Rogiers V, Vinken M. Ramboer E, et al. J Hepatol. 2014 Oct;61(4):925-43. doi: 10.1016/j.jhep.2014.05.046. Epub 2014 Jun 6. J Hepatol. 2014. PMID: 24911463 Free PMC article. Review.
Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell cycle is a complex process that is tightly regulated by several well-established mechanisms. In vitro, isolated hepatocytes do not long …
Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell …
A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues.
Spitzer D, Khel MI, Pütz T, Zinke J, Jia X, Sommer K, Filipski K, Thorsen F, Freiman TM, Günther S, Plate KH, Harter PN, Liebner S, Reiss Y, Di Tacchio M, Guérit S, Devraj K. Spitzer D, et al. Nat Protoc. 2023 May;18(5):1510-1542. doi: 10.1038/s41596-023-00805-y. Epub 2023 Mar 1. Nat Protoc. 2023. PMID: 36859615 Review.
The gating strategy encompasses cell-type-specific and exclusion markers for contaminating cells to isolate the major NVU cell types. ...The EPAM-ia method is also amenable to isolation of several other cell types, including cancer cells and imm …
The gating strategy encompasses cell-type-specific and exclusion markers for contaminating cells to isolate the major NVU c …
Infiltrating CD8(+) T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.
Jorfi M, Park J, Hall CK, Lin CJ, Chen M, von Maydell D, Kruskop JM, Kang B, Choi Y, Prokopenko D, Irimia D, Kim DY, Tanzi RE. Jorfi M, et al. Nat Neurosci. 2023 Sep;26(9):1489-1504. doi: 10.1038/s41593-023-01415-3. Epub 2023 Aug 24. Nat Neurosci. 2023. PMID: 37620442
To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising stem cell-derived neurons, astrocytes and microglia, together with peripheral immune cells. ...Using single-cell RNA-sequencing, we id …
To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising stem cell …
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation.
Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A. Bergert M, et al. Cell Stem Cell. 2021 Feb 4;28(2):209-216.e4. doi: 10.1016/j.stem.2020.10.017. Epub 2020 Nov 17. Cell Stem Cell. 2021. PMID: 33207217 Free PMC article.
To adopt a different shape, cells need to change the mechanical properties of their surface. ...By mechanically tethering the plasma membrane to the cortex by enhancing Ezrin activity or expressing a synthetic signaling-inert linker, we demonstrate that preventing this det …
To adopt a different shape, cells need to change the mechanical properties of their surface. ...By mechanically tethering the plasma …
The neurovascular unit in leukodystrophies: towards solving the puzzle.
Zarekiani P, Nogueira Pinto H, Hol EM, Bugiani M, de Vries HE. Zarekiani P, et al. Fluids Barriers CNS. 2022 Feb 28;19(1):18. doi: 10.1186/s12987-022-00316-0. Fluids Barriers CNS. 2022. PMID: 35227276 Free PMC article. Review.
The neurovascular unit (NVU) is a highly organized multicellular system localized in the brain, formed by neuronal, glial (astrocytes, oligodendrocytes, and microglia) and vascular (endothelial cells and pericytes) cells. The blood-brain barrier, a complex an …
The neurovascular unit (NVU) is a highly organized multicellular system localized in the brain, formed by neuronal, glial (astrocytes …
A Human Neurovascular Unit On-a-Chip.
Lee SWL, Rogosic R, Venturi C, Raimondi MT, Pavesi A, Adriani G. Lee SWL, et al. Methods Mol Biol. 2022;2373:107-119. doi: 10.1007/978-1-0716-1693-2_7. Methods Mol Biol. 2022. PMID: 34520009
We developed a microfluidic-based model of the neurovascular unit. A monolayer of human cerebral endothelial cells (hCMEC-D3) was grown and cocultured with human brain microvascular pericytes (hBMVPC), and human induced pluripotent stem cells differentiated i …
We developed a microfluidic-based model of the neurovascular unit. A monolayer of human cerebral endothelial cells (hCMEC-D3) …
Protocols for in vitro Differentiation of Human Mesenchymal Stem Cells into Osteogenic, Chondrogenic and Adipogenic Lineages.
Ciuffreda MC, Malpasso G, Musarò P, Turco V, Gnecchi M. Ciuffreda MC, et al. Methods Mol Biol. 2016;1416:149-58. doi: 10.1007/978-1-4939-3584-0_8. Methods Mol Biol. 2016. PMID: 27236670
Mesenchymal stem cells (MSC) possess high plasticity and the potential to differentiate into several different cell types; this characteristic has implications for cell therapy and reparative biotechnologies. ...MSC are able to differentiate in vitro and in v …
Mesenchymal stem cells (MSC) possess high plasticity and the potential to differentiate into several different cell types; thi …
Two-Step Co-Immunoprecipitation (TIP).
Sciuto MR, Coppola V, Iannolo G, De Maria R, Haas TL. Sciuto MR, et al. Curr Protoc Mol Biol. 2019 Jan;125(1):e80. doi: 10.1002/cpmb.80. Epub 2018 Oct 30. Curr Protoc Mol Biol. 2019. PMID: 30375742
Here, we report a detailed TIP procedure that we used to purify a protein-protein complex from Burkitt lymphoma cells and from primary human CD4(+) T cells. In addition, this unit describes an application of TIP for the isolation of transcription-factor-bound …
Here, we report a detailed TIP procedure that we used to purify a protein-protein complex from Burkitt lymphoma cells and from primar …
Regeneration of the neurogliovascular unit visualized in vivo by transcranial live-cell imaging.
Arango-Lievano M, Dromard Y, Fontanaud P, Lafont C, Mollard P, Jeanneteau F. Arango-Lievano M, et al. J Neurosci Methods. 2020 Sep 1;343:108808. doi: 10.1016/j.jneumeth.2020.108808. Epub 2020 Jun 20. J Neurosci Methods. 2020. PMID: 32569784 Review.
Real-time optical imaging of brain functions is limited by light scattering, skull distortion, timing resolution and subcellular precision that altogether, make challenging the rapid acquisition of uncorrupted functional data of cells integrated de novo in the neurogliovas …
Real-time optical imaging of brain functions is limited by light scattering, skull distortion, timing resolution and subcellular precision t …
An engineered neurovascular unit for modeling neuroinflammation.
Seo S, Choi CH, Yi KS, Kim SU, Lee K, Choi N, Lee HJ, Cha SH, Kim HN. Seo S, et al. Biofabrication. 2021 May 5;13(3). doi: 10.1088/1758-5090/abf741. Biofabrication. 2021. PMID: 33849004
The neurovascular unit (NVU) comprises multiple types of brain cells, including brain endothelial cells, astrocytes, pericytes, neurons, microglia, and oligodendrocytes. ...Here, we present a three-dimensional (3D) immortalized human cell-based NVU mod …
The neurovascular unit (NVU) comprises multiple types of brain cells, including brain endothelial cells, astrocytes, pe …
316,210 results
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